2025-06-27
Neurodegenerative diseases like Parkinson’s remain some of the most pressing challenges in medicine. Despite decades of research, their root causes and progression pathways are still...
At the intersection of neuroscience, aging, and regenerative medicine, the Drouin-Ouellet Lab investigates the fundamental mechanisms of Parkinson’s Disease (PD). We focus on understanding how aging contributes to PD and explore innovative cell reprogramming strategies to develop models and therapies for neurodegeneration.
We are based in the Faculty of Pharmacy at the Université de Montréal and welcome students, collaborators, and partners who share our passion for translational neurobiology.
Our lab integrates advanced in vitro human models with state-of-the-art molecular and imaging technologies to investigate the role of aging in Parkinson’s Disease. We specialize in:
We investigate whether Parkinson’s Disease is a form of accelerated aging or the result of dysfunction in specific aging pathways, using patient-derived neuronal models to pinpoint root causes and therapeutic targets.
Astrocytes in the aging brain show altered biology that may impact both disease progression and their potential for neural repair. Our lab studies astrocyte aging and their reprogramming potential to restore brain function.
Microglia exhibit a strong inflammatory response in PD. We use senescent microglial models to uncover how aging alters immune responses and contributes to neurodegeneration in Parkinson’s Disease.
Stay up to date with our recent discoveries, lab milestones, and scientific contributions in the field of aging and Parkinson’s Disease.
Neurodegenerative diseases like Parkinson’s remain some of the most pressing challenges in medicine. Despite decades of research, their root causes and progression pathways are still...
We’re thrilled to announce that Zaya Haj Mohamad, MSc student in the Drouin-Ouellet Lab, has been awarded a Master’s scholarship from the Fonds de recherche...
In response to various stressors, cells can enter a state called cellular senescence which is characterized by irreversible cell cycle arrest and a senescence-associated secretory...
Through cutting-edge models and human cellular reprogramming, we aim to understand how aging contributes to neurodegeneration and how it might be reversed.
